[Objective] To explore anti-aging effect of high-dosage compound PSP(polysaccharide from Spirulina platensis),so as to lay a foundation for further exploitation and utilization of Spirulina platensis and Ginkgo biloba resources.[Method] Mice were fed with compound medicines every day,as well as their napes of neck were injected D-galactose by subcutaneously daily for successive 42 days.Effects of high-dosage compound PSP and Ginkgo biloba extracts on D-galactose-induced aging model mice were investigated in terms of determining some decrepitude indexes,including weight of immune organs,SOD activity in serum and MDA content in myocardium and brain.[Result] PSP had strong anti-aging effects on mice caused by the injection of 125 mg/kg·d D-galactose for successive 42 days.[Conclusion] PSP was provided with the effects of antioxidation and anti-aging that may be related to polyhydroxy structure. [Objective] To explore anti-aging effect of high-dosage compound PSP (polysaccharide from Spirulina platensis), so as to lay a foundation for further exploitation and utilization of Spirulina platensis and Ginkgo biloba resources. [Method] Mice were fed with compound medicines every day, as well as their napes of neck were injected D-galactose by subcutaneously daily for 42 days. Effects of high-dosage compound PSP and Ginkgo biloba extracts on D-galactose-induced aging model mice were investigated in terms of determining some decrepitude indexes, including weight of immune organs, SOD activity in serum and MDA content in myocardium and brain. [Result] PSP had strong anti-aging effects on mice caused by the injection of 125 mg / kg · d D-galactose for successive 42 days. [Conclusion] PSP was provided with the effects of antioxidation and anti-aging that may be related to polyhydroxy structure.