The year of 2020 witnessed a “great pandemic unseen in a century” breaking out globally and spreading continuously, which has posed not only a huge threat to the health and lives of mankind, but also a formidable challenge to the global public health system. In addition to exposing many problems in the field of international politics, the pandemic also accelerated the evolving trend of the world order. In the post-COVID-19 era, the international balance of power is to undergo profound changes, geopolitics will return, multilateral cooperation will be faced with serious challenges, and the international order is to take on new characteristics on the basis of existing trends. In the face of such a complex international situation, how to correctly understand the changes, scientifically respond to the changes, and actively initiate changes have become major tasks of China’s diplomacy.