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现有抗抑郁药物临床起效缓慢,因此需要研发快速起效抗抑郁药物。植物挥发油显示具有快速起效抗抑郁潜能,首先,挥发油气味芳香能够直接刺激嗅神经,脂溶性高易于透过血脑屏障,挥发性强适合鼻腔脑靶向和吸入给药,能够快速调节脑功能,具有快速起效抗抑郁潜能;其次,抗抑郁活性植物挥发油化学和药理研究进展揭示了挥发油抗抑郁化学物质基础、抗抑郁效果及可能作用机制;再者,考察植物挥发油抗抑郁活性成分对快速起效抗抑郁靶点作用,发现植物挥发油化学成分能拮抗NMDA受体活性,提示植物挥发油具有快速起效抗抑郁靶点机制潜能;最后,探讨通过整合抗抑郁挥发油特性、快速起效抗抑郁靶点机制和给药方式,充分发挥植物挥发油快速起效抗抑郁优势,为新药研发提供方向。
Existing antidepressants have slow onset of clinical efficacy and therefore require the development of rapidly acting antidepressant drugs. Botanical volatile oils show rapid onset of antidepressant potential. First of all, volatile oils smell aroma that directly stimulates the olfactory nerve, high lipophilicity easily penetrates the blood-brain barrier, is highly volatile and is suitable for nasal brain targeting and inhalation administration, and is capable of rapidly regulating brain function , Has rapid onset of antidepressant potential; Second, the anti-depressant activity of volatile oil chemical and pharmacological research reveals the chemical basis of anti-depressant volatile oil, antidepressant effect and possible mechanism; In addition, the study of anti-depressant plant volatile oil components of rapid It is found that the chemical constituents of plant volatile oil can antagonize the activity of NMDA receptors, suggesting that the plant volatile oil has the potential mechanism of rapid onset of antidepressant targets. Finally, it explores the rapid onset of antidepressant target by integrating the properties of antidepressant volatile oil Point mechanism and mode of administration, give full play to the rapid onset of plant volatile oil anti-depressant advantages for research and development of new drugs to provide direction.