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目的探讨乙型肝炎病毒药物治疗后基因类型转化情况。方法对2004年我院肝病门诊103例已作过乙型肝炎病毒基因分型的患者,分别进行拉米夫定和干扰素治疗,治疗停药一年后,复检乙型肝炎病毒基因类型。结果103例病人中,65例用拉米夫定治疗,29例用干扰素治疗,9例用其它核苷类药物治疗,停药后复查患者基因类型,除5例未分析出结果外,98例患者通过药物治疗基因类型均未改变。结论乙型肝炎病毒不管是否经过药物治疗,其基因类型在一定时期内是不会发生基因类型改变的。
Objective To investigate the genotype transformation of Hepatitis B virus after drug treatment. Methods A total of 103 hepatitis B virus (HBV) genotype patients were enrolled in our hospital in 2004. The patients were treated with lamivudine and interferon respectively. After one year of withdrawal from treatment, the HBV genotypes were reexamined. Results Of the 103 patients, 65 were treated with lamivudine, 29 were treated with interferon, 9 were treated with other nucleosides, and the patient’s genotype was reviewed after discontinuation, with the exception of 5 patients not yet analyzed The patients treated with the drug did not change the genotype. Conclusion Hepatitis B virus does not undergo genetic modification after a certain period of time, regardless of whether the drug is administered or not.