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本文对20例胃癌细胞原发性MDR1mRNA水平进行检测，并且对其影响肿瘤细胞mdr－1基因表达的因素采用多因素电子计算机Logistic回归模型进行分析。结果显示：胃癌细胞MDR1mRNA表达与年龄、性别、肿瘤的大小、分期、分化程度等因素之间无统计学关系（P＞0．1）；与肿瘤的淋巴结转移（P＝0．0107）、局部组织浸润（P＝0．0009）关系密切。提示：胃癌病人术后化疗方案的设计应根据肿瘤细胞mdr－1基因检测结果而拟定。对术中肿瘤已有淋巴结转移和（或）已有局部组织浸润的胃癌病人，应尤为重视其MDR1mRNA表达的检测，以选择最适宜的化疗方案，达到满意的化疗目的。
In this paper, the primary MDR1 mRNA levels in 20 gastric cancer cells were detected, and factors that affect the mdr-1 gene expression in tumor cells were analyzed using a multi-factor computer logistic regression model. The results showed that there was no statistical relationship between MDR1 mRNA expression and age, gender, tumor size, stage, differentiation degree and other factors (P>0.1); lymph node metastasis with tumor (P=0.0107), local Tissue infiltration (P=0.0009) is closely related. Tip: The design of postoperative chemotherapy for gastric cancer patients should be based on the mdr-1 gene detection results of tumor cells. For patients with gastric cancer who have already had lymph node metastasis and/or have local tissue infiltration, it should pay special attention to the detection of MDR1 mRNA expression to select the most appropriate chemotherapy regimen to achieve satisfactory chemotherapy.