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目的通过Meta分析比较肾炎康复片联合激素等西医常规疗法治疗肾病综合征(NS)的有效性。方法系统检索Pub Med、The Cochrane Library(2015年第12期)、Embase、CNKI、CBM、VIP、Wan-Fang数据库中相关临床随机对照试验(RCT),检索时限为各数据库建库至2015年12月23日。两名研究者独立地进行文献筛选、数据提取及文献质量评价。运用Rev Man5.3软件进行统计分析。结果共纳入10个RCT,合计NS患者755例。Meta分析结果显示,肾炎康复片联合激素等西医常规疗法与单一西医疗法在治疗有效率、减少24 h尿蛋白、增加血浆白蛋、降低胆固醇和三酰甘油等方面疗效差异有统计学意义,在降低血肌酐、尿素氮方面疗效差异无统计学意义。敏感性分析结果未发生明变化,漏斗图显示本研究无明显发表偏倚。结论肾炎康复片联合激素等西医常规法治疗肾病综合征疗效明显优于单一西医疗法,值得临床推广。
Objective To compare the effectiveness of traditional Chinese medicine such as nephritis and rehabilitation combined with traditional Chinese medicine in the treatment of nephrotic syndrome (NS) by Meta-analysis. Methods The related clinical randomized controlled trials (RCTs) of Pub Med, The Cochrane Library (December 12, 2015), Embase, CNKI, CBM, VIP and Wan-Fang databases were searched systematically. On the 23rd. Two researchers conducted independent literature screening, data extraction and literature quality evaluation. RevMan5.3 software for statistical analysis. Results A total of 10 RCTs were enrolled and 755 NS patients were enrolled. Meta analysis showed that the treatment of nephritis and traditional Chinese medicine combined with hormone and other Western conventional therapy in the treatment of effective, reduce 24 h urinary protein, increased plasma white eggs, lower cholesterol and triglyceride, etc. The difference was statistically significant Lower serum creatinine, urea nitrogen difference was not statistically significant. Sensitivity analysis results did not change significantly, funnel plots showed no significant published bias in this study. Conclusion The treatment of nephritic syndrome with traditional Chinese medicine such as nephritis and rehabilitation combined with hormones is obviously superior to single western medicine in clinical practice and is worthy of clinical promotion.