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目的观察岩舒注射液配合化疗(5-Fu/CF/DDP方案)对晚期胃癌的临床疗效。方法 96例患者随机分为治疗组和对照组,治疗组给予岩舒注射液配合5-Fu/CF/DDP方案化疗,对照组单纯给予5-Fu/CF/DDP方案化疗。结果治疗组有效率为43.8%,对照组为41.7%,两组比较差异无显著性(P>0.05);但治疗组稳定率为81.3%,对照组为70.8%,两组比较差异有显著性(P<0.05)。并且治疗组生活质量改善、症状改善、体重增加均优于对照组(P<0.05)。同时治疗组CD3、CD4、CD4/CD8水平的提高亦明显高于对照组(P<0.05)。治疗组的主要毒副反应明显减轻,尤其在消化道反应和骨髓抑制方面,两组比较差异均有显著性(P<0.05)。结论岩舒注射液联合5-Fu/CF/DDP方案化疗具有提高免疫功能和一定的减毒增效作用,可进一步改善症状、延缓疾病进展、提高生存质量。
Objective To observe the clinical effect of Yan Shu injection combined with chemotherapy (5-Fu / CF / DDP regimen) on advanced gastric cancer. Methods Ninety-six patients were randomly divided into treatment group and control group. The treatment group received Yan Shu injection combined with 5-Fu / CF / DDP regimen and the control group received 5-Fu / CF / DDP chemotherapy alone. Results The effective rate was 43.8% in the treatment group and 41.7% in the control group, with no significant difference between the two groups (P> 0.05). However, the stabilization rate was 81.3% in the treatment group and 70.8% in the control group, with significant difference between the two groups (P <0.05). And the quality of life improvement, symptom improvement, weight gain in the treatment group were better than the control group (P <0.05). At the same time, the levels of CD3, CD4 and CD4 / CD8 in the treatment group were significantly higher than those in the control group (P <0.05). The main side effects of the treatment group were significantly reduced, especially in the digestive tract reaction and bone marrow suppression, the difference between the two groups were significant (P <0.05). Conclusion Yanshu injection combined with 5-Fu / CF / DDP regimen can improve immune function and attenuate toxicity and synergism, further improve symptoms, delay disease progression and improve quality of life.