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肿瘤的发生与发展过程与机体免疫功能关系密切[1]。目前临床治疗肿瘤的常规方法包括手术、化疗和放疗,但因特异性较差,在杀伤肿瘤细胞的同时也对正常细胞和组织造成不同程度损伤,导致机体免疫功能异常或低下[2]。细胞因子诱导的杀伤(cytokine-induced killer,CIK)细胞,是指将人体外周血单个核细胞(PBMC)在体外分离并与多种细胞因子共培养后得到的异质性细胞群,具有增殖速度快、敏感性高、
Tumor occurrence and development process and immune function are closely related [1]. At present, the routine methods of clinical treatment of cancer include surgery, chemotherapy and radiotherapy. However, due to the poor specificity, the normal cells and tissues are damaged to a certain extent while killing the tumor cells, resulting in abnormal or low immunity of the organism [2]. Cytokine-induced killer (CIK) cells refer to heterogeneous cell populations obtained from human peripheral blood mononuclear cells (PBMCs) isolated in vitro and co-cultured with various cytokines, and have a proliferation rate Fast, high sensitivity,