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目的:比较雷替曲赛联合奥沙利铂及氟尿嘧啶联合奥沙利铂在进展期结直肠癌辅助化疗中的疗效与安全性。方法:选择100例进展期结直肠癌患者,将其随机分为两组,每组50例。一组采用雷替曲赛3mg/㎡联合奥沙利铂130mg/㎡,每三周重复;一组采用氟尿嘧啶500mg/㎡联合奥沙利铂130mg/㎡,每三周重复。两组均至少进行四个周期。结果:结论:雷替曲赛联合奥沙利铂三周方案在进展期结直肠癌患者辅助化疗中的疗效明显,且毒性反应轻,是治疗进展期结直肠癌患者的有效方案。
OBJECTIVE: To compare the efficacy and safety of raltitrexed with oxaliplatin and fluorouracil plus oxaliplatin in adjuvant chemotherapy for advanced colorectal cancer. Methods: 100 patients with advanced colorectal cancer were selected and randomly divided into two groups, 50 cases in each group. A group of 3mg / ㎡ with oxaliplatin 3mg / ㎡ of 130mg / ㎡, repeated every three weeks; a group of 500mg / ㎡ of fluorouracil combined oxaliplatin 130mg / ㎡, repeated every three weeks. Both groups are at least four cycles. Results: Conclusion: Rituximab combined with oxaliplatin three weeks regimen has obvious curative effect in adjuvant chemotherapy for patients with advanced colorectal cancer and mild toxic reaction, which is an effective treatment for patients with advanced colorectal cancer.