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目前国产酵母重组乙型肝炎 (乙肝 )疫苗已取代血源性乙肝疫苗 ,为了解国产酵母重组乙肝疫苗现场应用的免疫效果和阻断乙肝母婴传播的效果而进行了观察研究。应用深圳康泰生物制品有限公司生产的酵母重组乙肝疫苗 ,采用 0、1、6和 0、1、2二种程序 ,剂量均为 1针 5 μg ,全程 3针 ,对 166例HBsAg和HBeAg单、双阳性母亲所生的新生儿和 491例HBsAg阴性母亲所生的新生儿进行免疫接种。结果全部观察对象未发现严重不良反应。 0、1、6和 0、1、2程序两组HBsAg阴性母亲的新生儿全程免疫后 6个月 ,抗 -HBs阳转率为 92 79%和 91 0 4% ;HBsAg和HBeAg单、双阳性母亲的新生儿抗 -HBs阳转率为 82 97%和 81 94% ;0、1、6和 0、1、2程序两组的阻断保护率分别为 81 0 8%和 81 48%。此结果表明 ,国产酵母重组乙肝疫苗具有较好的免疫效果和阻断乙肝母婴传播的保护作用 ,但乙肝母婴传播的阻断率仍有待于进一步提高。
At present, the domestic yeast recombinant hepatitis B vaccine has replaced the blood-borne hepatitis B vaccine in order to understand the immune effect of the domestic yeast recombinant hepatitis B vaccine and the effect of blocking the mother-to-child transmission of hepatitis B. Application of Shenzhen Kangtai Biological Products Co., Ltd. yeast recombinant hepatitis B vaccine, using 0,1,6 and 0,1,2 two kinds of procedures, the dose was 1 pin 5 μg, the entire 3-pin, 166 cases of HBsAg and HBeAg single, Newborns born to double positive mothers and new born babies born to 491 HBsAg negative mothers were immunized. Results All the subjects did not find serious adverse reactions. The positive rate of anti-HBs was 92 79% and 91 0 4% at 6 months after whole-course immunization of HBsAg-negative mothers in 0, 1, 6 and 0, 1 and 2 procedures. HBsAg and HBeAg single and double positive The positive rate of anti-HBs mothers in newborns was 82 97% and 81 94% respectively. The blocking protection rates in the 0, 1, 6 and 0, 1 and 2 groups were 81 0% and 81 48% respectively. The results show that the recombinant yeast-derived hepatitis B vaccine has a good immune effect and block the protection of mother-to-child transmission of hepatitis B, but the blocking rate of hepatitis B virus transmission remains to be further improved.