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目的 了解玻璃体手术巩膜穿刺孔嵌顿的眼内组织是否表达了与血管生成相关的生长因子及其受体。 方法 在玻璃体手术中 ,共取 10例从巩膜穿刺孔脱出的眼内组织。冰冻切片 ,用免疫组织化学方法检查血管内皮生长因子 (vascular endothelial growth factor,VEGF)、碱性成纤维细胞生长因子(basic fibroblast growth factor,b FGF)、血小板源性生长因子 - A(platelet- derived growth factor- A,PDGF- A)、转化生长因子 - β1 (transforming growth factor,TGF- β1 )及其受体。 结果 脱出的眼内组织包括 :视网膜和玻璃体组织各 3例、变性的红细胞 2例 ,睫状体和纤维组织各 1例。VEGF和 b FGF及其受体在所有标本均为阳性 ,PDGF- A、TGF- β1 及其受体仅在大部分标本阳性。阳性染色包括了视网膜的细胞、睫状体色素细胞和非色素细胞、纤维细胞和部分玻璃体内的细胞。 结论 嵌顿在巩膜穿刺孔的眼内组织表达了与血管生成相关的生长因子及其受体 ,可能会参与前段增殖性玻璃体视网膜病变发生发展
Objective To investigate whether intraocular tissue implanted in vitreous surgery scleral puncture hole expresses angiogenesis-related growth factors and their receptors. Methods In vitreous surgery, a total of 10 cases of intraocular tissue prolapse from the scleral puncture were taken. Frozen sections were obtained. The expression of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (b FGF), platelet-derived growth factor-A, PDGF-A), transforming growth factor-β1 (TGF-β1) and its receptor. Results The prolapse of the intraocular tissue include: 3 cases of retina and vitreous tissue, 2 cases of degenerative erythrocytes, 1 case of ciliary body and fibrous tissue. VEGF and b FGF and their receptors were positive in all specimens, while PDGF-A, TGF-β1 and their receptors were positive only in the majority of specimens. Positive staining includes retinal cells, ciliary body pigment cells and non-pigmented cells, fibroblasts and some vitreous cells. Conclusion Implantation of scleral puncture in the eye tissue expression of angiogenesis-related growth factors and their receptors may be involved in the development of anterior proliferative vitreoretinopathy