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目的探讨二氧化碳激光联合胸腺五肽对女性尖锐湿疣的临床效果及免疫功能的影响。方法选取2014年10月-2016年4月重庆市巴南区人民医院收治的女性尖锐湿疣患者84例,采用随机数字表法分为两组,观察组采用二氧化碳激光联合胸腺五肽肌肉注射治疗,对照组采用二氧化碳激光治疗,观察对比两组患者6个月后的心理指标、免疫指标、复发率等。结果治疗后观察组Ig G(14.24±2.83)g/L、Ig A(3.19±0.89)g/L和Ig M(1.44±0.60)g/L均明显高于对照组(11.43±2.62)g/L、(2.80±0.73)g/L和(1.10±0.34)g/L,差异均有统计学意义(t=4.72、2.19、3.20,P<0.01);两组治疗后6个月随访发现观察组患者焦虑自评量表(SAS)和抑郁自评量表(SDS)评分[(45.38±12.30)分、(44.40±14.21)分]均明显低于对照组[(51.34±11.56)分、(55.32±13.12)分],差异均有统计学意义(t=2.28、3.65,P<0.01);观察组治疗后Th1/Th2比值为(0.95±0.20)明显高于对照组的(0.67±0.21),差异有统计学意义(t=6.25,P<0.01);观察组治疗后6个月内复发2例,占4.76%,对照组复发12例,占28.57%,差异有统计学意义(χ~2=8.58,P<0.01)。结论二氧化碳激光联合胸腺五肽肌肉注射可提高女性尖锐湿疣免疫功能,减少复发率并改善消极心态。
Objective To investigate the effect of carbon dioxide laser combined with thymopentin on the clinical efficacy and immune function of female genital warts. Methods Eighty-four female patients with condyloma acuminatum who were treated in Banan District People’s Hospital of Chongqing from October 2014 to April 2016 were randomly divided into two groups. The observation group was treated with intramuscular injection of carbon dioxide laser combined with thymopentin, The control group using carbon dioxide laser treatment, observed and compared two groups of patients after 6 months of psychological indicators, immune indicators, recurrence rate. Results After treatment, Ig G (14.24 ± 2.83) g / L, Ig A (3.19 ± 0.89) g / L and Ig M (1.44 ± 0.60) g / L were significantly higher in the observation group than those in the control group (11.43 ± 2.62) L, (2.80 ± 0.73) g / L and (1.10 ± 0.34) g / L respectively, with statistical significance (t = 4.72,2.19,3.20, P <0.01) The scores of SAS and SDS [(45.38 ± 12.30) and (44.40 ± 14.21) points were significantly lower than those of control group [(51.34 ± 11.56), ( 55.32 ± 13.12), the differences were statistically significant (t = 2.28,3.65, P <0.01). The Th1 / Th2 ratio in the observation group was significantly higher than that in the control group (0.95 ± 0.20) (0.67 ± 0.21) , The difference was statistically significant (t = 6.25, P <0.01). In the observation group, 2 cases recurred within 6 months (4.76%) and 12 cases (28.57%) in the control group, the difference was statistically significant (χ ~ 2 = 8.58, P <0.01). Conclusion CO2 laser combined with thymopentin intramuscular injection can improve the immune function of female genital warts, reduce the recurrence rate and improve the negative attitude.