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目的:探讨乙肝免疫球蛋白(HBIG)和乙肝疫苗联合阻断乙肝病毒(HBV)母婴传播的疗效。方法:选择2014年12月~2015年12月间246例HBs Ag阳性孕妇为研究对象,根据随机数字表法分为观察组及对照组,均123例。对照组仅新生儿单独接种乙肝疫苗,观察组孕妇及新生儿均联合接种乙肝疫苗和HBIG。结果:对照组及观察组新生儿中出现宫内HBV感染率分别为22.76%和9.76%,一年后对照组及观察组新生儿中HBV感染率分别16.26%和1.63%,两组间差异均存在统计学意义。对照组及观察组新生儿出生时及一年后对应HBs Ab阳性率分别为8.13%、76.42%和27.64%、94.31%,两组差异存在统计学意义。结论:孕妇及新生儿乙肝免疫球蛋白和乙肝疫苗联合应用能够有效降低HBs Ag阳性情况患者所产新生儿HBV感染率,同时能使新生儿对应的HBs Ab转阳率有效提高,最终使HBV的传播阻断率提高。
Objective: To investigate the efficacy of combination of hepatitis B immunoglobulin (HBIG) and hepatitis B vaccine in the prevention of mother-to-child transmission of hepatitis B virus (HBV). Methods: A total of 246 HBsAg-positive pregnant women from December 2014 to December 2015 were selected as study subjects and divided into observation group and control group according to random number table method, all of which were 123 cases. In the control group, only newborns were vaccinated with Hepatitis B vaccine. The pregnant women and newborns in the observation group were given hepatitis B vaccine and HBIG in combination. Results: The intrauterine HBV infection rates in control group and observation group were 22.76% and 9.76% respectively. After one year, the HBV infection rates in control group and observation group were 16.26% and 1.63%, respectively. The differences among the two groups were There is statistical significance. The positive rates of HBs Ab in the control group and the observation group at birth and one year after the birth were 8.13%, 76.42% and 27.64%, 94.31% respectively. There was a significant difference between the two groups. Conclusion: The combined use of hepatitis B immunoglobulin and hepatitis B vaccine in pregnant women and newborns can effectively reduce the neonatal HBV infection rate in patients with HBsAg-positive status and effectively increase the positive rate of HBs Ab transfection in newborns, Propagation block rate increased.