7-ACA经三甲基硅基取代、碘代、Wittig反应、脱保护,一锅法制得关键中间体7-ATCA,再经酰化、成钠盐和酯化得头孢妥仑匹酯,总收率为35%。7-ATCA及头孢妥仑匹酯经1H NMR和MS确证结构。该方法反应步骤少、操作简便、原料易得,较适合工业化生产。 7-ACA by trimethylsilyl substitution, iodination, Wittig reaction, deprotection, one-pot method of the key intermediate 7-ATCA, followed by acylation, sodium salt and esterification of cefditoren pivoxil, the total The yield is 35%. 7-ATCA and cefpotramide were confirmed by 1H NMR and MS. The method has few reaction steps, is easy to operate, is easily obtained from raw materials, and is suitable for industrialized production.