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目的:探讨中国北方地区血清钙、维生素D水平与乳腺癌及相关临床因素的关系。方法:选取2007年12月至2012年7月哈尔滨医科大学附属肿瘤医院794例女性乳腺癌患者及976例乳腺良性肿瘤患者,并以128例健康妇女为对照,取空腹血清采用原子吸收分光光度法检测三组血清钙含量,采用放免法检测三组中162例血清25(OH)D含量,结合相关临床资料进行分析。结果:乳腺癌组血清钙含量为2.26±0.12 mmol/L,乳腺良性肿瘤组血清钙含量为2.26±0.09 mmol/L,正常对照组血清钙含量为2.25±0.24 mmol/L,经方差分析,三组总体均数差别无统计学意义(P>0.05);乳腺癌患者的血清钙水平与年龄、TNM分期、BMI、绝经情况、乳腺癌家族遗传史无关(P>0.05)。乳腺癌组血清25(OH)D含量为41.91±7.55 ng/mL,乳腺良性肿瘤血清25(OH)D含量为54.62±7.48 ng/mL,正常对照组血清25(OH)D含量为56.15±8.87 ng/mL,经方差分析,乳腺癌患者血清25(OH)D含量低于乳腺良性肿瘤组,差别有统计学意义(P<0.05),乳腺良性肿瘤组与正常对照组差别无统计学意义(P>0.05);乳腺癌患者的维生素D水平与年龄、TNM分期、BMI、绝经情况有关(P<0.05),而与乳腺癌家族遗传史无关(P>0.05)。结论:中国北方地区的乳腺癌患者血清钙水平与乳腺良性肿瘤患者无明显差异。乳腺癌患者的维生素D水平低于乳腺良性肿瘤患者,并且与年龄、TNM分期、BMI、绝经情况有关。维生素D水平降低可能与乳腺癌的发生有关,高水平的维生素D可能会降低女性患乳癌的风险。
Objective: To investigate the relationship between serum calcium and vitamin D levels and breast cancer and related clinical factors in northern China. Methods: From December 2007 to July 2012, 794 cases of breast cancer patients and 976 cases of breast benign tumor in Affiliated Tumor Hospital of Harbin Medical University were enrolled. A total of 128 healthy women were selected as control. Fasting serum was collected by atomic absorption spectrophotometry Serum calcium levels were measured in three groups. The levels of serum 25 (OH) D in 162 serum samples from three groups were detected by radioimmunoassay, and the related clinical data were analyzed. Results: Serum calcium was 2.26 ± 0.12 mmol / L in breast cancer, 2.26 ± 0.09 mmol / L in breast benign tumor, and 2.25 ± 0.24 mmol / L in normal control group. By ANOVA, There was no significant difference between the two groups (P> 0.05). The level of serum calcium in breast cancer patients was not related to age, TNM stage, BMI, menopause, and family history of breast cancer (P> 0.05). The serum 25 (OH) D content in breast cancer patients was 41.91 ± 7.55 ng / mL, the serum 25 (OH) D content in benign breast tumors was 54.62 ± 7.48 ng / mL, and the normal control group serum 25 (OH) D content was 56.15 ± 8.87 The serum 25 (OH) D level in patients with breast cancer was lower than that in benign breast tumors by statistical analysis of variance (P <0.05). There was no significant difference between the benign tumor group and normal control group (P < P <0.05). The level of vitamin D in breast cancer patients was related to age, TNM stage, BMI and menopause (P <0.05), but not to breast cancer family history (P> 0.05). Conclusion: There is no significant difference between serum calcium level in breast cancer patients and benign breast tumors in northern China. The level of vitamin D in breast cancer patients is lower than that in benign breast tumors and is related to age, TNM stage, BMI and menopause. Decreased levels of vitamin D may be associated with the development of breast cancer, and high levels of vitamin D may reduce the risk of breast cancer in women.