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目的:评价IL-1α和IL-1β指标变化对慢性乙型肝炎(CHB)患者的诊断及其临床意义。方法:选取2012年8月—2013年7月间收治的CHB患者40例为观察组和对照组(健康志愿者)40例;两组患者均采用酶联免疫法(ELISA)测定其血清中IL-1α和IL-1β含量,分析IL-1α和IL-1β含量的变化对诊断CHB的临床意义。结果:观察组患者血清中IL-1α和IL-1β含量均高于健康对照组(P<0.01);其含量的变化与CHB患者临床特征(HBVDNA、ALT和AST)无相关性。结论:IL-1α和IL-1β可能参与CHB的疾病进程,这为研究CHB的病情变化的监控及其有效治疗提供新的依据。
Objective: To evaluate the changes of IL-1α and IL-1β in patients with chronic hepatitis B (CHB) diagnosis and its clinical significance. Methods: Forty CHB patients admitted to our hospital from August 2012 to July 2013 were enrolled in the study. Forty CHB patients (control group and healthy volunteers) were enrolled in this study. Enzyme linked immunosorbent assay (ELISA) 1α and IL-1β levels in patients with CHB. The clinical significance of the changes of IL-1α and IL-1β levels in the diagnosis of CHB was analyzed. Results: The levels of IL-1α and IL-1β in serum of observation group were higher than those of healthy control group (P <0.01). The changes of serum IL-1α and IL-1β in serum of patients in observation group were not correlated with the clinical features (HBVDNA, ALT and AST) of CHB patients. Conclusion: IL-1α and IL-1β may be involved in the pathogenesis of CHB, which will provide a new basis for the study on the monitoring of CHB and its effective treatment.