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各种标记配体与阿片受体的结合受到多种离子及核甙酸的调节。其中以Na~+,Mg~(2+)和GTP研究较多。Snyder等人曾建议用钠商值区别激动剂、混合型激动-拮抗剂和拮抗剂,核甙酸中的GTP也能显著地影响激动剂和某些拮抗剂与阿片受体的结合。肝素钠为一天然多糖高分子混合物,具有很强的生理活性,人们利用肝素与雌激素受体的相互作用的特点,
The binding of various labeled ligands to opioid receptors is regulated by a variety of ions and nucleotides. Among them Na +, Mg 2+ and GTP are more studied. Snyder et al. Have suggested that agonists, mixed agonists - antagonists and antagonists be distinguished by sodium quotient. GTP in nucleotides can also significantly affect the binding of agonists and certain antagonists to opioid receptors. Heparin sodium is a natural polysaccharide polymer mixture, has a strong physiological activity, people use the characteristics of heparin and estrogen receptor interaction,