β-内酰胺类抗生素是迄今为止最有效而低毒的一类抗生素.关于这类抗生素和活细菌细胞的相互关系,人们提出了许多饶有兴趣的问题.诸如:β-内酰胺类具有什么样的结构特征才能引起选择性地抑制粘肽代谢?这类药物怎样通过细菌的外膜进入他们的生化靶部位?青霉素结合蛋白的功能是什么?粘肽代谢中对青霉素敏感酶有哪一些?青霉素分子如何抑制这些酶?这种抑制作用的细胞代谢和生理学结果又是什么?而最重 β-lactam antibiotics are by far the most effective and low-toxic class of antibiotics, and many interesting questions have been raised concerning the interrelationship between such antibiotics and viable bacterial cells, such as what are the β-lactams Like structural features can cause selective inhibition of mucin metabolism? How these drugs through the bacterial outer membrane into their biochemical target site? What is the function of penicillin-binding protein? Peptide metabolism in penicillin-sensitive enzymes? How do penicillin molecules inhibit these enzymes? What are the metabolic and physiological consequences of this inhibitory effect? ​​The heaviest