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本文报道pH指示剂吸收度比值法测定克霉唑的含量。该法采用指示剂为稀溴酚蓝,测定波长433nm和599nm;标准液为0.1mol/L盐酸;仪器为日本岛津260型分光光度计。应用本法测定5批克霉唑含量,同时与药典法比较,结果一致。
This article reports the pH indicator absorbance ratio method for the determination of clotrimazole content. The method uses the indicator for dilute bromophenol blue, determination of wavelength 433nm and 599nm; standard solution of 0.1mol / L hydrochloric acid; instrument Shimadzu 260 spectrophotometer. The application of this method to determine 5 batches of clotrimazole content, at the same time with the pharmacopoeia method, the results are consistent.