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目的研究HER2在结直肠癌的表达及意义。方法应用pathway array analysis方法分析了56例结直肠癌肿瘤组织及癌旁正常组织中HER2的表达。结果在56例结直肠癌患者中共发现HER2阳性表达35例,21例正常黏膜组织中HER2过表达,其中16例结直肠癌患者有淋巴结转移。结论 HER2的表达与结直肠癌的发生发展相关,检测HER2的表达可作为判断结直肠癌的生物学行为和预后的重要指标。
Objective To study the expression of HER2 in colorectal cancer and its significance. Methods The expression of HER2 in 56 cases of colorectal cancer tissues and adjacent normal tissues was analyzed by way of pathway array analysis. Results Of the 56 patients with colorectal cancer, HER2 positive expression was found in 35 cases and HER2 overexpression in 21 cases of normal mucosa, of which 16 cases had colorectal cancer with lymph node metastasis. Conclusion The expression of HER2 is correlated with the occurrence and development of colorectal cancer. Detecting the expression of HER2 may be an important index for judging the biological behavior and prognosis of colorectal cancer.