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酮舍林(Ketanserin)为5-羟色胺S_2受体选择性拮抗剂。本实验通过双盲、交叉、有安慰剂对照的随机试验,观察20名高血压患者口服酮舍林和美托洛尔后,两种药物对心脏和前臂血流动力学效应的比较。受试者分别口服酮舍林(第一周20mg,此后40mg,)或美托洛尔(100mg),均每日2次,共5周。结果,两药均能使舒张压和收缩压降低约10％,但对前臂血流动力学的作用彼此有明显差异。酮舍林使前臂血流量增加,并使前臂血管阻力明显下降(从对照值
Ketanserin is a serotonin S 2 receptor selective antagonist. In our randomized, double-blind, crossover, and placebo-controlled trial, the hemodynamic effects of two drugs on heart and forearm were compared after oral ketamine and metoprolol in 20 hypertensive patients. The subjects were orally given ketamine (20 mg in the first week, 40 mg thereafter) or metoprolol (100 mg) twice daily for 5 weeks. As a result, both drugs reduced diastolic and systolic blood pressure by about 10%, but their effects on forearm hemodynamics differed significantly from each other. Ketosin increased forearm blood flow and markedly decreased forearm vascular resistance (from control values)