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目的:顺铂热化疗对卵巢癌中PI3K/AKT与凋亡相关调控因子表达的影响。方法:收集我院收治的卵巢癌患者60例,随机分为对照组和实验组,每组各30例,对照组患者给予顺铂化疗方案,实验组患者在对照组基础上进行热疗。观察并比较两组患者治疗前后PI3K,AKT及CA125水平的变化情况以及临床疗效。结果:与治疗前相比,治疗后两组患者PI3K,AKT及CA125水平均下降,差异具有统计学意义(P<0.05);与对照组相比,实验组患者治疗后PI3K,AKT及CA125水平较低,差异具有统计学意义(P<0.05);实验组临床总有效率(80.0%)高于对照组(70.0%),差异具有统计学意义(P<0.05)。结论:与单纯应用顺铂相比,顺铂热化疗能够降低卵巢癌患者PI3K,AKT及CA125水平,提高临床疗效,对临床有指导意义。
Objective: To investigate the effect of Cisplatin on the expression of PI3K / AKT and apoptosis related regulators in ovarian cancer. Methods: Sixty patients with ovarian cancer who were admitted to our hospital were randomly divided into control group and experimental group, with 30 patients in each group. Patients in control group were given cisplatin chemotherapy regimen. Patients in experimental group were given hyperthermia on the basis of control group. The change of PI3K, AKT and CA125 levels before and after treatment and the clinical efficacy were observed and compared between the two groups. Results: Compared with those before treatment, the levels of PI3K, AKT and CA125 decreased after treatment in both groups (P <0.05). Compared with the control group, the levels of PI3K, AKT and CA125 (P <0.05). The total clinical effective rate (80.0%) in the experimental group was higher than that in the control group (70.0%), the difference was statistically significant (P <0.05). Conclusion: Compared with cisplatin alone, cisplatin thermochemotherapy can reduce the levels of PI3K, AKT and CA125 in patients with ovarian cancer and improve clinical curative effect, which is of clinical significance.