论文部分内容阅读
间质性膀胱炎或痛性膀胱炎的病因至今不明,有关学说之一系认为正常膀胱粘膜表面有一层含有糖蛋白、糖脂肪及硫化氨基葡萄聚糖粘液层、能阻止尿中有害物质及细菌进入膀胱壁,间质性膀胱炎的病因系由于该粘液保护层的缺损。合成的肝素样药物戊聚糖多硫酸钠(Sodium Pcntosanpolysulfate)具有硫化氨基葡聚糖的生化特性,与膀胱粘膜以较强亲合力,动物实验度初步临床应用可减轻间质性膀胱炎的症状。本期有三篇应用该药的报告,综合摘录如下。
The cause of interstitial cystitis or cystitis is unknown. One of the theories is that the normal bladder mucosa surface contains a layer of mucin that contains glycoproteins, sugar and glucosamine glucosaminoglycans, which can prevent harmful substances and bacteria in the urine Into the bladder wall, interstitial cystitis etiology is due to the mucus protective layer defects. Synthetic heparin-like drug pentosan polysulfate (Sodium Pcntosanpolysulfate) has the biochemical characteristics of sulfanilic dextran, with a strong affinity with the bladder mucosa, animal experiments preliminary clinical application can reduce the symptoms of interstitial cystitis. There are three reports of the current application of the drug, summarized as follows.