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目的探讨过敏性紫癜(HSP)患者的发病特点和复发因素。方法对201例HSP住院患者临床资料进行回顾性分析。结果 HSP好发年龄为6～15岁的青少年,男女比例1.3∶1,秋冬季发病率占66.20%,主要诱因是感染,皮疹是主要的临床表现,而消化道症状作为首发症状时易误诊。Logistic回归分析复发的危险因素:皮疹反复、肾脏损害、病程长(>1个月)、年龄大(>18岁)有统计学意义(P<0.05)。结论并发肾脏损害的成年患者病情易反复发作,早期进行干预性治疗和至少6周门诊随访检测肾功能是必要的。
Objective To investigate the onset and recurrence of patients with Henoch-Schonlein purpura (HSP). Methods 201 cases of HSP inpatients clinical data were retrospectively analyzed. Results The prevalence of HSP in adulthood was between 6 and 15 years. The ratio of male to female was 1.3:1. The incidence of autumn and winter was 66.20%. The main cause was infection and the rash was the main clinical manifestation. However, the symptoms of digestive tract were easily misdiagnosed as the first symptom. Logistic regression analysis of recurrence risk factors: repeated rashes, kidney damage, longer duration (> 1 month), older (> 18 years) was statistically significant (P <0.05). Conclusions Adult patients with renal impairment are prone to recurrent episodes. Early interventions and follow-up of at least 6 weeks of follow-up may be necessary.