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目的对比分析同时性结直肠癌肝转移行同期手术与分期手术切除转移灶的疗效。方法通过计算机文献检索ISI Web of Knowledge、Pubmed及中国期刊网,检索国内外自1990年1月至2010年12月间公开发表的有关结直肠癌肝转移治疗的文章。通过Meta分析对比同时性结直肠癌肝转移同期、分期术后围手术期并发症、死亡率、5年生存率。结果同时性结直肠癌肝转移同期手术切除组与分期手术切除组比较,同期手术组围手术期并发症发生率36.4%与分期手术组35.6%(P=0.957)相似,在围手术期死亡率(OR=1.91,95%CI:0.90～4.08,P=0.09)及5年生存率(OR=1.08,CI:0.73～1.61,P=0.69)方面无统计学差异。结论与分期切除相比,同时性结直肠癌肝转移行同期切除同样安全、有效。
Objective To compare and analyze the curative effect of concurrent resection and staged surgical resection of metastatic colorectal cancer with liver metastasis. METHODS: ISI Web of Knowledge, Pubmed and China Journal Net were retrieved from computer literature to search articles published at home and abroad from January 1990 to December 2010 on liver metastasis of colorectal cancer. By meta-analysis of simultaneous colorectal cancer liver metastasis at the same period, postoperative perioperative complications, mortality, 5-year survival rate. Results Compared with staging resection group, the incidence of perioperative complications in concurrent surgical resection group was 36.4%, which was similar to 35.6% (P = 0.957) in staging surgical operation group. The perioperative mortality rate (OR = 1.91, 95% CI: 0.90 ~ 4.08, P = 0.09) and 5-year survival rate (OR = 1.08, CI: 0.73-1.61, P = 0.69). Conclusions Compared with staging resection, synchronous resection of colorectal carcinoma with liver metastases is equally safe and effective.