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目的了解阿托伐他汀对颈动脉粥样硬化内中膜厚度的影响。方法选择对36例具有颈动脉粥样硬化的冠心病患者应用阿托伐他汀作为治疗组和同期只有颈动脉粥样硬化的非冠心病患者作为对照组,观察3个月、6个月时内中膜厚度的变化。结果治疗组在治疗6个月后内中膜厚度减小,与对照组比较,差异有显著性P<0.05。结论阿托伐他汀除降脂作用外,还有减轻动脉粥样硬化作用。
Objective To investigate the effect of atorvastatin on intima-media thickness in carotid atherosclerosis. Methods 36 cases of patients with carotid atherosclerosis with atorvastatin as the treatment group and only atherosclerotic carotid atherosclerotic non-coronary heart disease patients as a control group were observed at 3 months, 6 months Changes in the thickness of the tunica media. Results The thickness of intima of the treatment group decreased 6 months after treatment, and the difference was significant compared with the control group (P <0.05). Conclusion Atorvastatin has the effect of reducing atherosclerosis in addition to lipid-lowering effect.