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目的探讨小剂量奥氮平在胃肠道恶性肿瘤化疗患者的生存质量及依从性的影响。方法按照随机、对照、配对原则,将61例2003-12-2010-12在江阴市人民医院胃病专科住院的胃肠道恶性肿瘤化疗患者随机分为干预组30例和对照组31例,干预组在常规化疗同时,予以心理干预及口服小剂量奥氮平,对照组仅予以适当的心理安慰。采用SAS焦虑自评量表评价焦虑情绪。结果与对照组相比,干预组的情绪功能、社会功能、整体健康状态明显提高,化疗依从性明显优于对照组。结论常规心理干预联合小剂量奥氮平在胃肠道恶性肿瘤化疗中,能更有效的减少化疗不良反应的发生,减轻焦虑和抑郁,提高患者的依从性及生存质量,从而提高生存率。
Objective To investigate the effect of low-dose olanzapine on the quality of life and compliance of patients with gastrointestinal malignant tumor chemotherapy. Methods According to the principle of randomization, comparison and pairing, 61 patients with gastrointestinal cancer who were hospitalized in Gastroenterology of Jiangyin People’s Hospital from December 2003 to December 2010 were randomly divided into intervention group (n = 30) and control group (n = 31) In conventional chemotherapy at the same time, to psychological intervention and oral low-dose olanzapine, the control group was only appropriate psychological comfort. SAS anxiety scale was used to evaluate anxiety. Results Compared with the control group, the emotional function, social function and overall health of the intervention group were significantly improved, and the compliance of chemotherapy was significantly better than that of the control group. Conclusion Conventional psychological intervention combined with low-dose olanzapine can effectively reduce the incidence of adverse reactions in chemotherapy, reduce anxiety and depression, improve patient compliance and quality of life, and improve survival rate.