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本文报告自1981年11月至1983年9月用国产乙肝血源疫苗接种于e抗原阳性产妇之新生儿36名的5年观察,观察乙肝血源疫苗对e抗原阳性产妇所生婴儿免疫后抗体的持续时间和保护状态。36名中31人产生抗-HBs,5年时其中19名幼儿的抗-HBs仍在10mIu/ml以上,占61.29％,抗-HBs降到10mIu/ml以下者12名,占38.71％,高滴度抗体预示保护抗体持续的时间长。36名婴儿初免后,6个月内HBsAg阳转者5人,到5年时仍为阳性,均演变为HBsAg慢性携带者,携带率为13.88％,31名抗-HBs阳性的幼儿中,5年时有6人被HBV感染表现抗-HBC阳转,占19.94％,但其HBsAg仍为阴性,HBV感染与抗体滴度偏低有关。抗体消失或降到10mIu/ml以下时宜进行乙肝疫苗1剂再接种,以增强其免疫能力。
This article reports from November 1981 to September 1983 with domestic hepatitis B blood vaccine inoculated e antigen-positive mothers of 36 newborns in the observation of 5 years to observe the hepatitis B blood vaccine for e antigen-positive mothers of infants born after immunization antibodies The duration and protection status. Thirty-six of the 36 patients developed anti-HBs, and the anti-HBs of 19 infants were still above 10mIu / ml at 5 years, accounting for 61.29%, 12 of which were anti-HBs down to 10mIu / ml, accounting for 38.71% Titers of antibodies indicate long duration of antibody protection. After the initial immunization of 36 infants, 5 positive HBsAg positive mothers within 6 months were still positive at 5 years, all of whom were chronic carriers of HBsAg with a carrying rate of 13.88%. Of the 31 positive children with anti-HBs, At 5 years, 6 were positive for anti-HBC by HBV infection, accounting for 19.94%, but HBsAg was still negative, and HBV infection was associated with low antibody titer. When the antibody disappears or drops below 10mIu / ml, a hepatitis B vaccine should be re-inoculated to enhance its immunity.