发展了一类含有不同亚胺配体的氮杂环卡宾-钯配合物,并将其应用到Buchwald-Hartwig交叉偶联反应中.研究发现亚胺配体的结构对催化活性有明显的影响,尤其带有强吸电子基团的亚胺配体表现最佳.利用该类配合物可以在低至0.5 mol%的催化剂用量下实现不同氯代芳烃和各种胺的高效偶联反应. A class of heterocyclic heterocyclic carbene-palladium complexes with different imine ligands were developed and applied to the Buchwald-Hartwig cross-coupling reaction. It was found that the structure of the imine ligand significantly affected the catalytic activity, In particular, the imine ligands with strong electron-withdrawing groups performed the best, and the efficient coupling reaction of different chlorinated aromatics with various amines can be achieved with these complexes at catalyst levels as low as 0.5 mol%.