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目的 :研究 2型糖尿病患者发生脑梗死时血清TXB2 与 6 keto PGF1α的变化特点。 方法 :测定本组病人血清TXB2 和 6 keto PGF1α水平 ,并检测其空腹血糖、餐后血糖、糖化血红蛋白、纤维蛋白原、甘油三酯、胆固醇、高密度脂蛋白、低密度脂蛋白的水平。结果 :2型糖尿病合并急性脑梗死组的血清TXB2 水平与单纯 2型糖尿病组、非糖尿病急性脑梗死组间的差异均有统计学意义 (P <0 .0 5 ) ,而血清 6 keto PGF1α水平的差异无统计学意义(P >0 .0 5 ) ;TXB2 水平在单纯 2型糖尿病组与非糖尿病急性脑梗死组间的差异无统计学意义 (P >0 .0 5 ) ,但血清 6 keto PGF1α水平差异有统计学意义 (P <0 .0 5 )。本组所有病人血清TXB2 水平与血清GHbA1C、TG、LDL水平均呈正相关 (P <0 .0 5 ) ,与血清HDL水平呈负相关 (P <0 .0 5 ) ;血清 6 keto PGF1α水平与血清 2 hPG、LDL水平均呈负相关 (P <0 .0 5 )。在单纯 2型糖尿病病人中 ,血清TXB2 水平与血清GHbA1C、TC、LDL水平呈正相关 (P<0 .0 5 ) ,血清 6 keto PGF1α水平与 2 hPG、LDL水平呈正相关 (P <0 .0 5 )。结论 :TXA2 PGI2 平衡失调在脑梗死的发生中 ,尤其是 2型糖尿病发生脑梗死中起着重要的作用。同时 ,TXA2 PGI2 平衡失调是 2型糖尿病的糖和脂代谢紊乱的?
Objective: To study the changes of serum TXB2 and 6 keto PGF1α in type 2 diabetic patients with cerebral infarction. Methods: The serum levels of TXB2 and 6 keto PGF1α in the patients were measured. The levels of fasting blood glucose, postprandial blood glucose, glycosylated hemoglobin, fibrinogen, triglycerides, cholesterol, high density lipoprotein, and low density lipoprotein were measured. Results: The serum TXB2 level in type 2 diabetic patients with acute cerebral infarction was significantly lower than that in type 2 diabetic patients and non-diabetic acute cerebral infarction patients (P <0.05), while serum 6 keto PGF1α (P> 0.05). There was no significant difference in TXB2 level between simple type 2 diabetes mellitus group and non-diabetic acute cerebral infarction group (P> 0.05), but serum 6 keto PGF1α levels were significantly different (P <0.05). Serum TXB2 levels in all the patients were positively correlated with serum GHbA1C, TG and LDL levels (P <0.05), but negatively correlated with serum HDL levels (P <0.05). Serum levels of 6 keto PGF1α and serum 2 hPG, LDL levels were negatively correlated (P <0. 05). In patients with type 2 diabetes, serum TXB2 level was positively correlated with serum GHbA1C, TC, LDL levels (P <0.05), serum 6 keto PGF1α level was positively correlated with 2 hPG and LDL levels (P <0.05) ). Conclusion: The imbalance of TXA2 PGI2 plays an important role in the occurrence of cerebral infarction, especially in type 2 diabetes mellitus. Meanwhile, TXA2 PGI2 balance disorders are type 2 diabetes, glucose and lipid metabolism disorder?