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目的探讨糠酸莫米松鼻喷雾剂联合通窍鼻炎片治疗变应性鼻炎的临床疗效。方法选取2014年11月—2016年7月荆门市中医医院(石化医院)接收的变应性鼻炎患者124例,按照随机双盲法将患者分为试验组与对照组,各62例。试验组予以糠酸莫米松鼻喷雾剂+通窍鼻炎片治疗,对照组予以糠酸莫米松鼻喷雾剂。比较两组患者临床疗效、不良反应发生情况、白介素-4(IL-4)与γ干扰素(IFN-γ)水平、症状评分。结果试验组总有效率高于对照组,试验组患者IL-4水平低于对照组,IFN-γ水平高于对照组(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。治疗前两组患者症状评分比较,差异无统计学意义(P>0.05)。治疗后试验组患者症状评分低于对照组(P<0.05)。结论糠酸莫米松鼻喷雾剂联合通窍鼻炎片治疗变应性鼻炎的临床疗效确切,可有效缓解患者症状,且不良反应少。
Objective To investigate the clinical efficacy of mometasone furoate nasal spray and Tongqiao rhinitis tablet in the treatment of allergic rhinitis. Methods 124 patients with allergic rhinitis received from Jingmen Hospital of Traditional Chinese Medicine (Sinopec Hospital) from November 2014 to July 2016 were randomly divided into experimental group and control group according to a randomized double-blind method, with 62 cases in each group. The experimental group was treated with mometasone furoate nasal spray + Tongqiao rhinitis tablets, while the control group was given mometasone furoate nasal spray. The clinical efficacy, incidence of adverse reactions, interleukin-4 (IL-4) and interferon-gamma (IFN-γ) levels and symptom scores were compared between the two groups. Results The total effective rate of the experimental group was higher than that of the control group. The level of IL-4 in the experimental group was lower than that of the control group, and the level of IFN-γ was higher than that of the control group (P <0.05). Two groups of patients with adverse reactions, the difference was not statistically significant (P> 0.05). There was no significant difference in symptom score between the two groups before treatment (P> 0.05). After treatment, symptom scores of test group were lower than those of control group (P <0.05). Conclusion Mometasone furoate nasal spray and Tongqiao rhinitis tablets are effective in treating allergic rhinitis and can effectively relieve the symptoms of patients with less adverse reactions.