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目的:研究慢性阻塞性肺病(COPD)患者血清基质金属蛋白酶(Matrix metalloproteinase,MMP)-9和金属蛋白激酶组织抑制物(Tissue inhibitors of metalloproteinases,TIMPs)-1的含量,以探讨TIMP-1,MMP-9与气道阻塞之间的关系。方法:收集86例COPD患者,43例支气管哮喘患者以及70例对照患者的静脉血,利用ELISA方法测定上述血清TIMP-1和MMP-9含量,并对COPD患者进行呼吸功能测定,我们还对TIMP-1和MMP-9含量与第一秒用力肺活量进行相关性分析。结果:COPD患者血清TIMP-1含量(195.0±6)ug/ml显著高于对照组(117.5±5.4)ug/L和哮喘组(165.1±14.3)ug/L,并与COPD患者的第一秒用力肺活量呈负相关性;MMP-9/TIMP-1比值低于对照组,在COPD急性加重期TIMP-1含量升高。结论:血清TIMP-1含量在COPD气道阻塞和急性加重期升高明显。
Objective: To investigate the levels of serum matrix metalloproteinase (MMP) -9 and tissue inhibitors of metalloproteinases-1 (TIMPs) -1 in patients with chronic obstructive pulmonary disease (COPD) -9 and airway obstruction. Methods: The venous blood of 86 patients with COPD, 43 patients with bronchial asthma and 70 controls were collected. The serum levels of TIMP-1 and MMP-9 were measured by ELISA and the respiratory function was measured in patients with COPD. We also measured TIMP -1 and MMP-9 levels and the first second forced vital capacity were analyzed. Results: The serum level of TIMP-1 in COPD patients (195.0 ± 6) ug / ml was significantly higher than that in control group (117.5 ± 5.4) ug / L and asthma group (165.1 ± 14.3) ug / L, Forced vital capacity was negatively correlated; the ratio of MMP-9 / TIMP-1 was lower than that of the control group, and the level of TIMP-1 was increased in the acute exacerbation of COPD. Conclusion: The serum level of TIMP-1 increased significantly in airway obstruction and acute exacerbation of COPD.