视网膜神经节细胞是视网膜发育中第一个产生的神经元,它的分化由视网膜前体细胞的内部信号和视网膜微环境的外部信号共同决定。Math5是Ath5在小鼠的表达形式,后者是视网膜神经节细胞分化的必要基因,但视网膜神经节细胞的分化还需要其他基因共同参与。本文就Math5 对视网膜神经节细胞的分化调控及其与其他基因的相互作用作一综述。 Retinal ganglion cells are the first neurons in the development of the retina whose differentiation is determined by both the internal signals of the retinal precursor cells and the external signals of the retina microenvironment. Math5 is an expression of Ath5 in mice, which is an essential gene for retinal ganglion cell differentiation. However, the differentiation of retinal ganglion cells requires the co-participation of other genes. This article reviews the regulation of the retinal ganglion cells by Math5 and its interaction with other genes.