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目的:探讨尼莫地平联合阿司匹林对急性缺血性脑梗死患者血清S100蛋白、神经元特异性烯醇化酶(NSE)、C反应蛋白(CRP)的影响及其二级预防作用.方法:急性缺血性脑梗死患者152例,按治疗的不同分为阿司匹林组及联合治疗组.比较2组治疗前后血清S100、NSE、CRP的水平,以及二级预防效果.结果:2组治疗后第7天及第15天的血清S100的水平差异有统计学意义,联合治疗组血清中S100、NSE、CRP水平低于阿司匹林组,差异有统计学意义(P<0.05).联合治疗组在脑梗死复发、并发心肌梗死以及下肢深静脉血栓的比例较阿司匹林组低,差异有统计学意义(P0.05).结论:尼莫地平联合阿司匹林能有效降低急性缺血性脑梗死患者血清中S100、NSE、CRP水平,且能降低脑梗死复发率、心肌梗死率及下肢深静脉血栓形成的比例.“,”Objective: To investigate the effects of nimodipine and aspirin on serum S100 protein (S100), neuron-specific enolase(NSE),and C reactive protein(CRP)in patients with acute ischemic cerebral infarction as well as its effect in secondary prevention.Methods:One hundred and fifty-two patients with acute ischemic cerebral infarction were divided into the aspirin group and the combination treatment group according to their different treatment procedures. Serum levels of S100, NSE, and CRP were compared between the two groups before and after treatment, and secondary prevention conferred by the treatment methods was also compared. Results: The difference in serum levels of S100 between the two groups at 7 days and 15 days after treatment was statistically significant. The serum levels of S100, NSE, and CRP in the combination therapy group were significantly lower than those in the aspirin group (P<0.05).The proportion of patients with recurrent cerebral infarction complicated with myocardial infarction and deep vein thrombosis (DVT) in the combined treatment group was significantly lower than that in the aspirin group(P0.05). Conclusion:Nimodipine combined with aspirin can effectively reduce serum levels of S100,NSE,and CRP in patients with acute ischemic cerebral infarction and can also reduce the recurrence rate of cerebral infarction, myocardial infarction,and DVT.