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目的 :观察去甲长春碱 (Navelbine ,NVB)加顺铂 (Cisplatin ,DDP)治疗非小细胞肺癌 (nonsmallcelllungcancer ,NSCLC)的疗效和安全性。方法 :治疗NSCLC 2 6例 ,采用NVB 30mg/m2 静脉推入 ,第1、8天 ;DDP 2 0mg静脉点滴 ,连用 5天。结果 :部分缓解 (PR) 10例 ,稳定 (SD) 8例 ,进展 (PD) 4例 ,总有效率 4 5 4 %。NVB的主要毒性反应为骨髓抑制 ,白细胞下降占 61 5% ,其中 3、4度占 34 6%。其他毒性反应有恶心呕吐 ( 53 9% ) ,局部静脉炎 ( 36 7% )。结论 :NVB加DDP联合治疗NSCLC有一定的疗效 ,对既往化疗无效的患者可作为挽救化疗方案使用。毒性主要为骨髓抑制 ,可用G CSF治疗
Objective: To observe the efficacy and safety of Navelbine (NVB) plus cisplatin (DDP) in the treatment of nonsmallcelllungcancer (NSCLC). Methods: 26 cases of NSCLC were treated with intravenous injection of NVB 30 mg / m2 on days 1 and 8; DDP 20 mg intravenously for 5 days. Results: There were 10 cases of partial remission (PR), 8 cases of stable (SD) and 4 cases of progressive (PD). The total effective rate was 45.4%. The main toxicity of NVB is myelosuppression, leukopenia 61 5%, of which 3,4 degrees accounted for 34 6%. Other toxic reactions were nausea and vomiting (53 9%), local phlebitis (36 7%). Conclusion: NVB plus DDP combined with NSCLC has some curative effect. Patients who are ineffective with previous chemotherapy can be used as salvage chemotherapy. Toxicity is mainly myelosuppression, available G CSF treatment