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【目的】以大剂量维生素D3造成婴幼儿脏器损害的严重后果警示临床。【方法】通过肾脏B超、颅脑CT检查,发现44例婴幼儿大剂量使用维生素D32～3年后出现脏器异位钙化。以健康儿为对照组测定了血清β2微球蛋白。【结果】肾脏B超钙质沉着症29例(65.91%),颅脑CT异常9例(20.45%),颅脑CT及肾脏B超均有改变6例(13.64%)。血清β2微球蛋白异位钙化组与对照组比较有统计学意义(t=4.68,P<0.05)。【结论】大剂量维生素D制剂可造成婴幼儿脏器异位钙化和持续性肾脏功能损伤,其远期影响尚需观察。临床必须警惕维生素D制剂的滥用。
【Objective】 Caused clinically the serious consequences of organ damage in infants and young children with high doses of vitamin D3. 【Methods】 Kidney B ultrasound, brain CT examination found that 44 cases of infants and young children using large doses of vitamin D after 32 years of ectopic calcification. Serum β2 microglobulin was measured in healthy children as control group. 【Results】 There were 29 cases (65.91%) of renal B hypercalcemia, 9 cases (20.45%) of abnormal brain CT, 6 cases (13.64%) of brain CT and renal B ultrasound. Serum β2 microglobulin ectopic calcification group compared with the control group was statistically significant (t = 4.68, P <0.05). 【Conclusion】 High-dose vitamin D preparations can cause ectopic calcification and persistent renal dysfunction in infants and young children. The long-term effects need to be observed. Clinic must guard against the abuse of vitamin D preparations.