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应用感染D型肝炎病毒（HDV）的猩猩和人血清分别接种上拨鼠（Woodchuck）肝炎病毒（WHV）感染的和未感染的动物。所获结果显示，来自于猩猩和来自人的HDV，均能使携带有WHV的10只上拨鼠全部感染，而非携带有WHV的土拨鼠则不能感染，证明人类的HDV不仅可以由人至猩猩的感染，而且还可以由猩猩至上拨鼠的感染;人至猩猩的感染并未改变HDV从HBsAg为外壳复制，而猩猩至上拨鼠的感染则以WHV的表面抗原（WHAg）为外壳，在动物体内高效复制，由于感染WHV的土拨鼠肝纤维化期短且能在2～3年内形成肝细胞癌。这为研究HBV／HDV感染的慢性化，肝纤维化和肝细胞癌的发生，发展提供了难得的极有价值的材料。
Orangutans and human sera infected with Hepatitis D virus (HDV) were inoculated with Woodchuck hepatitis virus (WHV) -infected and non-infected animals, respectively. The results obtained showed that all the HDVs from orangutans and human beings were fully infected with 10 male rats carrying WHV and not from groundhogs carrying WHVs, demonstrating that human HDV can not only be infected by humans To the orangutan infection, but also by the gorillas. The human-to-orangutan infection did not alter the replication of the HDV from the HBsAg, whereas the infection of the gorillas with the toppling mice was based on the WHV surface antigen (WHAg) Highly reproducible in animals due to a short period of liver fibrosis in woodchucks infected with WHV and capable of forming hepatocellular carcinoma within 2-3 years. This provides a rare and valuable material for studying the chronicity of HBV / HDV infection, liver fibrosis and the occurrence and development of hepatocellular carcinoma.