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目的总结鼻和咽部原发性非霍奇金淋巴瘤的临床特点,提高及时确诊率。方法回顾性分析收治的资料完整并经病理确诊的原发性鼻和咽部非霍奇金淋巴瘤17例的临床资料。结果鼻腔和鼻窦非霍奇金淋巴瘤患者首发症状包括鼻塞、流涕、鼻出血和外鼻畸形。鼻咽部非霍奇金淋巴瘤患者表现为耳鸣和听力下降,口咽部非霍奇金淋巴瘤患者表现为咽部异物感、咽痛、吞咽困难等。鼻和咽部原发性非霍奇金淋巴瘤临床表现无特异性,新生物表面有大量坏死组织,对可疑患者需要局麻或全麻下反复活检。结论鼻和咽部原发性非霍奇金淋巴瘤临床症状多不典型,易造成误诊、漏诊,及时行病理活检是确诊鼻和咽部原发性非霍奇金淋巴瘤的主要手段。
Objective To summarize the clinical features of nasal and pharyngeal primary non-Hodgkin’s lymphoma and to improve the timely diagnosis rate. Methods The clinical data of 17 patients with primary nasal and pharyngeal non-Hodgkin’s lymphoma who were diagnosed as complete and pathologically confirmed were analyzed retrospectively. Results The first signs of nasal and sinus non-Hodgkin’s lymphoma included nasal congestion, runny nose, nosebleeds and nasal deformities. Nasopharyngeal non-Hodgkin’s lymphoma patients showed tinnitus and hearing loss, oropharyngeal non-Hodgkin’s lymphoma showed pharyngeal foreign body sensation, sore throat, swallowing difficulties. Nasal and pharyngeal non-Hodgkin’s lymphoma non-specific clinical manifestations of new biological surfaces with a large number of necrotic tissue, suspected patients need local anesthesia or repeated biopsies under general anesthesia. Conclusion The clinical symptoms of primary non-Hodgkin’s lymphoma in the nasopharynx and pharynx are mostly atypical, which may lead to misdiagnosis, missed diagnosis and biopsy in time. It is the main method to diagnose primary non-Hodgkin’s lymphoma in nasal and pharynx.