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目的分析两种注射用第一类疫苗同时接种后预防接种不良事件(AEFI)的发生率,以评价其安全性。方法通过上海市长宁区9个社区预防接种门诊现场2006年3月～2007年12月登记流水册,统计乙型肝炎疫苗(HepB)第3针、A群脑膜炎球菌多糖疫苗(MCV-A)第1针、麻疹疫苗(MV)第1针和乙脑疫苗(JEV)第1针单独及同时接种的人数,计算AEFI的发生率。结果单独接种HepB第3针和MCV-A第1针的AEFI的发生率分别为5.86‰和3.74‰,同时接种时为1.18‰;单独接种MV和JEV第1针的AEFI发生率分别为3.59‰和9.24‰,同时接种时为1.93‰。同种疫苗不同厂家之间,或相同厂家不同包装剂量之间,AEFI发生率差异较大。AEFI发生率在6～12月龄儿童中较高。结论两种注射用第一类疫苗同时接种不会增加AEFI的发生率,为减少接种次数,可推荐同时接种。
Objective To analyze the incidence of vaccination adverse events (AEFI) after the simultaneous vaccination of the two first vaccines with vaccines to evaluate their safety. Methods A total of 9 HepB hepatitis B vaccines (MCV-A) were enrolled from 9 community vaccination clinics in Changning District of Shanghai from March 2006 to December 2007. AEFI was calculated on the basis of the number of people who received the first needling, the first needle of measles vaccine (MV), and the first needle of Japanese Encephalitis (JEV) vaccine. Results The incidences of AEFI in the third needle of HepB and the first needle of MCV-A alone were 5.86 ‰ and 3.74 ‰, respectively, and 1.18 ‰ at the time of inoculation. The incidences of AEFI in MV and JEV needle 1 were 3.59 ‰ And 9.24 ‰, at the same time when inoculation was 1.93 ‰. The same vaccine between different manufacturers, or the same manufacturer of different packaging doses, AEFI greater differences in the incidence. AEFI incidence in children 6 to 12 months of age higher. Conclusions The simultaneous vaccination of the two kinds of vaccines with the first type of vaccine will not increase the incidence of AEFI. In order to reduce the frequency of vaccination, simultaneous inoculation may be recommended.