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目的 :探讨慢性胃炎患儿幽门螺杆菌 (HP)感染与病理性胃食管反流 (GER )的相关性。方法 :所有病例都作胃镜检查和粘膜组织学检查 ,诊断慢性胃炎HP阳性 2 6例 ,HP阴性 17例 ,采用便携式食管 pH自动记录仪 ,监测两组患儿的食管 2 4hpH值 ,对监测结果进行对比研究。结果 :HP阳性的慢性胃炎发生病理性GER 6/2 6例 (占 2 3 0 8% ) ,HP阴性的慢性胃炎发生病理性GER 6/17例 (占 3 5 2 9% ) ,两组差异无显著性 (P >0 0 5 )。HP阳性组pH <4反流次数和最长酸反流时间小于HP阴性组 ,差异有显著性 (P <0 0 5 )。反流 >5min次数 ,pH <4总时间 ,pH <4时间百分比和食管清除率两组差异无显著性 (P >0 0 5 )。结论 :HP感染与病理性GER的发生无明显相关。
Objective: To investigate the relationship between Helicobacter pylori (HP) infection and pathological gastroesophageal reflux (GER) in children with chronic gastritis. Methods: Gastroscopy and mucosal histology were performed in all cases. Twenty-six cases of HP were diagnosed in chronic gastritis and 17 cases were negative in HP. A portable esophageal pH automatic recorder was used to monitor the esophageal 24 hpH in both groups. The monitoring results Conduct a comparative study. Results: Pathological GER 6/2 (2380%) occurred in HP positive chronic gastritis and pathological GER 6/17 (3529%) in HP negative chronic gastritis. The difference between the two groups No significant (P> 0.05). The positive rate of pH <4 and the longest acid reflux in HP positive group were less than those in HP negative group, the difference was significant (P <0.05). Reflux> 5min, pH <4 total time, pH <4 time percentage and esophageal clearance rate was no significant difference between the two groups (P> 0.05). Conclusion: There is no significant correlation between HP infection and pathological GER.