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以我国狂犬病固定毒人二倍体细胞适应株 (CTN - 1)作Vero细胞适应传代研究。显示CTN - 1株能较好适应Vero细胞 ,经 5代培养病毒滴度可达 7 5logLD5 0 /ml,且在 5～ 2 0代以内均稳定在 7 0logLD5 0 /ml左右 ,符合WHO对生产用毒种滴度要求
Adaptation of Rabies Stable Toxotrophic Diploid Cell (CTN - 1) to Vero Cells for Adaptation. The results showed that CTN - 1 strain could be adapted to Vero cells well, and the titer of 5 strains could reach 7 5 log LD50 / ml within 5 to 20 generations, and stabilized at 70 log LD50 / ml within 5 to 20 generations. Toxicity requirements