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目的探讨2型糖尿病(T2DM)合并急性初发及复发脑梗死患者血清脂联素(ADP)、超敏C反应蛋白(hs-CRP)水平的变化,以及两者与T2DM及脑梗死的一些危险因素的相关性。方法对单纯T2DM患者60例(A组),T2DM合并初发脑梗死患者120例(B组),T2DM合并复发脑梗死患者122例(C组),对照组60例(D组,不伴有脑梗死及T2DM者),分别采用ELISA法及放射免疫比浊法测定血清ADP及hs-CRP水平。结果 (1)A、B、C组血清ADP水平明显低于D组,hs-CRP水平明显高于D组(均P<0.05);(2)B、C组血清ADP水平明显低于A组,hs-CRP水平明显高于A组(均P<0.05);(3)C组血清ADP水平明显低于B组,hs-CRP水平明显高于B组(均P<0.05);(4)ADP与hs-CRP水平成显著负相关(r=0.856,P<0.01)。结论血清ADP水平降低及hs-CRP水平增高均是T2DM合并脑梗死的独立危险因素,两者均可作为预测脑梗死复发的检测指标。
Objective To investigate the changes of serum adiponectin (ADP), high-sensitivity C-reactive protein (hs-CRP) and the risk of T2DM and cerebral infarction in type 2 diabetes mellitus (T2DM) patients with acute and recurrent cerebral infarction Correlation of factors. Methods Sixty patients with T2DM (group A), 120 patients with T2DM complicated with primary cerebral infarction (group B), 122 patients with T2DM complicated with recurrent cerebral infarction (group C) and 60 patients with control group (group D) Cerebral infarction and T2DM). Serum ADP and hs-CRP levels were measured by ELISA and radioimmunoassay. Results (1) Serum ADP levels in groups A, B and C were significantly lower than those in group D and hs-CRP levels were significantly higher than those in group D (all P <0.05). (2) Serum ADP levels in groups B and C were significantly lower than those in group A (P <0.05); (3) The level of serum ADP in group C was significantly lower than that in group B, the level of hs-CRP was significantly higher than that in group B (all P <0.05); (4) There was a significant negative correlation between ADP and hs-CRP levels (r = 0.856, P <0.01). Conclusions The decrease of serum ADP level and the increase of hs-CRP level are independent risk factors for T2DM complicated with cerebral infarction, both of which can be used as a predictor of recurrent cerebral infarction.