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目的：探讨分析重症呼吸衰竭的临床危险因素及护理要点。方法：选择在我院接受治疗的50例重症呼吸衰竭患者为研究对象，按照抽签法将所有患者随机分成观察组和对照组，平均每组25例，观察组实施综合护理，对照组实施常规护理。结果：观察组的总有效率为92.0%，明显高于对照组的68.0%，P<0.05；观察组的呼吸功能复常时间和住院时间均明显优于对照组，P<0.05。结论：重症呼吸衰竭患者的临床危险因素主要包括合并高黏血症、自身的心脏功能较差、气道堵塞、酸碱平衡紊乱以及氧疗浓度不当等，加强对重症呼吸衰竭患者的观察护理，实施综合护理措施，能够明显提高患者的治疗效果。“,”objective To study the analysis of the clinical risk factors for severe respiratory failure and nursing key points. Methods In our hospital for treatment of 50 cases of patients with severe respiratory failure as the research object, according to the draw Method:of all patients were randomly divided into observation group and control group, an average of 25 cases in each group, implement comprehensive nursing observation group, control group routine nursing. Results The total effective rate was 92.0%, the observation group is significantly higher than the control group 68.0%, P<0.05;Observation group of respiratory function after often time and hospital stay were significantly better than the control group, P<0.05). Conclusion Severe respiratory failure in patients with clinical risk factors mainly include combining high blood sticky, poor heart function, their, and blockage of the airway, concentration of acid-base balance disorders and oxygen cure improper and so on, to strengthen the nursing of patients with severe respiratory failure, implement comprehensive nursing measures, can significantly improve the therapeutic effect of patients.