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目的:了解干扰素抗体(抗-IFN)在慢性丙型肝炎干扰素(IFN)治疗中的意义.方法:应用ELISA法对49例应用基因重组α2b干扰素(rIFNα2b)治疗的慢性丙型肝炎患者的抗-IFN进行检测.结果:疗程结束后24 49%(12/49)抗-IFN阳性.抗-IFN出现在治疗后2.95±1.25个月.抗体水平与治疗效果有关,高浓度抗体临床效果差.抗-IFN阳性者较阴性者治疗效果差,复发率高(P=0.0056).结论:抗-IFN产生可影响IFN抗病毒效果,降低临床疗效,可作为IFN治疗中预测疗效的指标之一.
Objective: To investigate the significance of interferon-α (IFN-γ) in the treatment of chronic hepatitis C interferon (IFN) .Methods: 49 patients with chronic hepatitis C treated with rIFNα2b Anti-IFN was detected in 24 49% (12/49) of the patients at the end of the course of treatment.Anti-IFN was observed at 2.95 ± 1.25 months after treatment.The level of antibody was related to the therapeutic effect, and the clinical effect of high concentration of antibody Poor anti-IFN positive than the negative treatment effect is poor, the recurrence rate was high (P = 0.0056) .Conclusion: anti-IFN production can affect the IFN antiviral effect and reduce the clinical efficacy of IFN therapy can be used as an index of predictive efficacy one.