【摘 要】
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Pluripotent stem cells (PSCs) can immortally self-renew in culture with a high proliferation rate,and they possess unique metabolic characteristics that facilit
【机 构】
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State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of
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Pluripotent stem cells (PSCs) can immortally self-renew in culture with a high proliferation rate,and they possess unique metabolic characteristics that facilitate pluripotency regulation.Here,we review recent pro.gress in understanding the mechanisms that link cellular metabolism and homeostasis to pluripotency regulation,with partlcular emphasis on pathways involving amino acid metabolism,lipid metabolism,the ubiqultln-proteasome system and sutophagy.Metabollsm of amino acids and llplds is tightly coupled to epigenetic modification,organelle remodeling and cell slgnallng pathways for plurlpotancy regulatlon.PSCs harness enhanced proteasome and autophagy activity to meet the material and energy requirements for cellular homeostasis.These regulatory events reflect a fine balance between the intrlnslc cellular requirements and the extrlnslc environment.A more complete understanding of thls balance will pave new ways to manipulate PSC fate.
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