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白介素-10(IL-10)是一个有力的抗炎和免疫调节因子,它通过抑制炎症因子和趋化因子的合成、抑制细胞介导的免疫反应,从而起到抗炎和免疫调节作用.本文就IL-10的分子生物学特点、细胞分布、IL-10的启动子区域的几个基因的多态性与肺部感染性疾病的关系作一综述.
Interleukin-10 (IL-10) is a potent anti-inflammatory and immunoregulatory agent that acts as an anti-inflammatory and immunoregulatory agent by inhibiting the synthesis of inflammatory cytokines and chemokines and inhibiting cell-mediated immune responses. The molecular biological features of IL-10, cell distribution, polymorphism of several genes in IL-10 promoter region and pulmonary infectious diseases were reviewed.