论文部分内容阅读
目的检测血清胆红素、C-C趋化因子受体1(CCR1)、血清肌钙蛋白I和白细胞介素6(IL-6)在急性心肌梗死(AMI)患者血浆中的水平。方法采用重氮法检测AMI组(65例)和正常对照组(65例)血清总胆红素(TBIL)及直接胆红素(DBIL)水平,ELISA检测血浆CCR1水平;化学发光法分别测定2组血清肌钙蛋白I水平,放射免疫分析法检测IL-6的水平。结果与正常对照组相比,AMI组TBIL为(15.07±2.87)μmol/L、IBIL为(9.32±4.58)μmol/L,低于对照组[TBIL(20.15±3.26)μmol/L、IBIL(14.48±3.90)μmol/L](P<0.05);AMI组CCR1、肌钙蛋白I、IL-6分别为(3.76±0.85)ng/mL、(15.88±2.43)U/mL、(207.60±23.94)U/mL,显著高于对照组[CCR1(0.66±0.19 ng/mL)、肌钙蛋白I(0.33±0.07)U/mL、IL-6(103.55±16.86)U/mL](P<0.05)。结论 AMI患者血清胆红素水平降低、而CCR1、肌钙蛋白I、IL-6水平升高。
Objective To detect the levels of serum bilirubin, C-C chemokine receptor 1 (CCR1), serum troponin I and interleukin 6 (IL-6) in patients with acute myocardial infarction (AMI). Methods Serum total bilirubin (TBIL) and direct bilirubin (DBIL) levels were measured by diazo method in AMI group (65 cases) and normal control group (65 cases), and plasma CCR1 levels were measured by ELISA. Chemiluminescence Serum troponin I levels were measured by radioimmunoassay to detect IL-6 levels. Results Compared with the normal control group, the TBIL in AMI group was (15.07 ± 2.87) μmol / L and that in IBIL group was (9.32 ± 4.58) μmol / L, lower than that in the control group [TBIL (20.15 ± 3.26) μmol / (3.76 ± 0.85) ng / mL, (15.88 ± 2.43) U / mL, (207.60 ± 23.94) μmol / L, P <0.05) U / mL was significantly higher than that in the control group [CCR1 (0.66 ± 0.19 ng / mL), troponin I (0.33 ± 0.07) U / mL and IL-6 (103.55 ± 16.86) U / mL] . Conclusion Serum bilirubin levels in patients with AMI decreased, while levels of CCR1, troponin I and IL-6 increased.