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目的:研究红细胞膜总胆固醇含量(CEM)与急性冠状动脉综合征(ACS)的相关性。方法:204例胸痛患者行冠状动脉造影后分成ACS组98例,稳定型心绞痛(SAP)组45例和对照组61例。采用酶学的方法测定各组CEM水平,用ELISA法测定血清高敏C反应蛋白(hs-CRP)水平。结果:ACS组CEM值为(149.50μg/mg,120.33～180.11μg/mg),较SAP组(79.98μg/mg,56.75～97.56μg/mg)及对照组(76.64μg/mg,62.12～91.84μg/mg)均明显增高(均P<0.05)。多因素逻辑回归分析提示CEM与ACS发病显著相关(OR24.990,95%CI5.220～119.596,P<0.01)。CEM水平与血清hs-CRP呈显著正相关(r=0.328,P<0.01)。结论:CEM可能通过炎症反应参与ACS发病的进程,是动脉粥样易损斑块的一个潜在标记物,对于ACS的预测作用优于hs-CRP。
Objective: To study the correlation between the total cholesterol content of erythrocyte membrane (CEM) and acute coronary syndrome (ACS). Methods: A total of 204 patients with chest pain were divided into ACS group (n = 98), stable angina pectoris group (n = 45) and control group (n = 61) after coronary angiography. The level of serum C-reactive protein (hs-CRP) was measured by enzyme-linked immunosorbent assay (ELISA). Results: Compared with SAP group (79.98μg / mg, 56.75 ~ 97.56μg / mg) and control group (76.64μg / mg, 62.12 ~ 91.84μg) / mg) were significantly higher (all P <0.05). Multivariate logistic regression analysis showed that CEM was significantly associated with the onset of ACS (OR24.990, 95% CI 5.220-119.596, P <0.01). There was a significant positive correlation between CEM level and serum hs-CRP (r = 0.328, P <0.01). CONCLUSION: CEM may participate in the pathogenesis of ACS through inflammatory reaction and is a potential marker of atherosclerotic plaque. Prediction of ACS is superior to that of hs-CRP.