目的 :探讨米非司酮配伍米索前列醇抗早孕的疗效。方法 :对宫内妊娠小于 49d ,自愿接受药流 ,无药流禁忌证的早孕妇女 132 8例 ,分为A ,B两组。A组 (6 71例 ) :第 1天上午空腹或进食 2h后口服米非司酮 15 0mg ,隔 48h服米索前列醇 0 6mg ;B组 (6 5 7例 ) :第 1天上午空腹或进食 2h后口服米非司酮2 5mg ,每天 2次 ,连服 3d ,第 4天上午服米索前列醇 0 6mg。结果 :A组成功率 94 3% ,B组成功率 88 43% ,两组成功率比较 ,差异有显著意义 (P <0 0 1)。结论 :米非司酮 15 0mg 1次顿服法药流成功率明显高于15 0mg ,分 6次连续 3d口服法 Objective: To investigate the efficacy of mifepristone and misoprostol in preventing pregnancy. Methods: 132 8 pregnant women who had received intrauterine pregnancy less than 49 days and received drug abstinence without contraindication were divided into A and B groups. Group A (671 cases): on the first day after fasting or eating 2h after oral administration of mifepristone 150mg, 48h misoprostol 0 6mg; B group (657 cases): the first day of fasting or 2h after eating oral mifepristone 25mg, 2 times a day, and even served 3d, the first 4 days morning taking misoprostol 0 6mg. Results: The success rate of group A was 94.3% and that of group B was 88.43%. There was significant difference between the success rates of group A and group B (P <0.01). CONCLUSION: The success rate of mifepristone 150 mg once-daily method was significantly higher than that of 15 0 mg, which was divided into 6 consecutive 3-d oral administrations