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目的评估螺旋CT(SCT)引导下125I粒子种植治疗中晚期肺癌近期疗效及预后影响因素。方法对黄河中心医院2008年11月至2012年4月52例失去手术适应证、不耐受放化疗或不愿接受手术的中晚期肺癌患者进行125I粒子种植治疗,评价近期疗效及对预后相关因素进行分析。结果粒子种植后3个月SCT复查:CR 14例,PR 28例,SD 4例,PD 6例,总有效率88.4%;6个月复查,CR 16例,PR 22例,SD 6例,PD 8例,总有效率84%。8例术中出现气胸,肺压缩10%～30%,4例行胸腔闭式引流术;8例术中及术后咳血或痰中带血,经对症处理后缓解;15例术后觉局部疼痛,对症处理后逐步缓解。无大出血、感染和癌灶种植等并发症。结论125I种植治疗中晚期肺癌,创伤小,并发症发生率低,近期疗效良好。
Objective To evaluate the short-term curative effect and prognostic factors of 125I seed implantation under the guidance of spiral CT (SCT) in the treatment of advanced lung cancer. Methods Fifty-two I seeds were implanted in 52 patients with advanced lung cancer who lost their indications of surgery, intolerant to chemoradiation or unwilling to undergo surgery from November 2008 to April 2012 in the Yellow River Central Hospital. The curative effect and prognostic factors Analyze. RESULTS: SCT was performed at 3 months after implantation: 14 cases were CR, 28 cases were PR, 4 cases were SD and 6 cases were PD. The total effective rate was 88.4%. Six months later, CR 16, PR 22, SD 6, PD 8 cases, the total efficiency of 84%. 8 cases of pneumothorax, pulmonary compression 10% to 30%, 4 cases of closed thoracic drainage; 8 cases of intraoperative and postoperative hemoptysis or bloody sputum, after symptomatic treatment and relief; 15 cases of postoperative Local pain, symptomatic treatment gradually ease. No major bleeding, infection and foci of complications such as planting. Conclusion 125I planting in the treatment of advanced lung cancer, less trauma, the incidence of complications is low, the recent good effect.